For any drug developer or service provider, cell line development is one of the most challenging phases, especially when subsequent GMP compliance is required.
To boost and support successful commercial introduction of biological drugs to the market, Celonic has engineered CHOvolution™, a cell line development platform for the generation of high-level expression cell lines for new biological entities (NBEs) and biosimilar products.
This is an innovative integrated cell line kit that can be used for a broad range of applications, ranging from non‑GMP R&D testing to GMP development and commercial market supply, with a support system to help throughout every step of development.
CHOvolution™ Key features:
CHOvolution™ is based on a CHO-K1 host cell line, a set of high level expression vectors and extensively refined protocols for the best screening and selection processes. The development strategy is based on a regulatory-compliant method for cloning, transfection, selection and single-cell cloning.
The CHOvolution™ cell lines from Celonic are highly stable upon scale-up and enable the best output worldwide for biopharma production performance.
Celonic has worked extensively on the development of expression vectors, cell lines and media, resulting in its proprietary serumfree expression platform technology, SEFEX (SErum Free EXpression) for the development of high-yield production cell lines without using gene amplification.
Celonic's CHOvolution™ kit comes with a wide range of exceptional services and solutions, on top of the high performance cells, delivering commercial success. In addition to robust and highly efficient technology, Celonic offers excellent technical support, including comprehensive protocols, audits, tailored workshops and a 24-7 information access internet-based platform with a hotline.
We look forward to helping you with your projects. Mr Stavros Theocharidis is available to answer any enquiries about cell lines and cell culture, as well as discuss with you the new opportunities we can develop for you as your provider and partner.
Phone: +41 61 202 94 25