Downstream Processing (DSP)

Celonic exhibits the know-how and equipment for the efficient and rapid development of purification strategies. The equipment is suited to scale up the purification into industrial scales. We provide Aekta chromatography systems, micro-, ultra- and tangential flow filtration systems as well as nanofiltration for virus removal. The generic process established by Celonic for the purification of monoclonal antibodies and fusion proteins comprises cell removal from culture broth, a concentration, protein A-capture, intermediary und polishing purification, ultra-/diafiltration and finally virus filtration. At every step, we succeed in keeping a recovery yield of higher than 95 %. In total, we are able to reach a recovery yield of more than 80 % for monoclonal antibodies and fusion proteins.