CHOvolution™: An extremely productive and stable CHO-based expression system for biopharmaceuticals

CHOvolution™ is a CHO-K1 based expression platform that can be used for a broad range of applications, ranging from non‑GMP R&D testing to GMP development and commercial market supply, with a support system to help throughout every step of development.

Besides offering cell line development services, Celonic is selling/outlicensing the system to other service providers or drug developers.

The CHOvolution™ technology is proven for:

  • Antibodies of different isotypes (e.g. IgG1, IgG2, IgG4)
  • Bispecific and single chain antibodies
  • Enzymes, growth factors and hormones

Its key features are :

  • Cell line adapted to serum-free EMA and FDA-compliant media
  • Simplified licensing model (e.g. no royalties from sales)
  • High productivity (up to 7.6 g/l for mABs)
  • High scale-up stability (over the 120 generation cycles and easily scalable from shake flask to >1000L)
  • GMP-compliant, from R&D to market manufacturing
  • Tailored workshops and hands-on training to develop the product
  • Technical and scientific support on the CHOvolution™ platform


GEX®: An enabling technology platform for expression of biopharmaceuticals which require a specific and/or fully human glycosylation profile.

The GEX® technology allows the optimization of glycosylation to improve activity and/or other properties like bioavailability, stability, and/or immunogenicity for better clinical performance.

It is based on human cell lines which are optimized for both product quality optimization and fast, high reproducible and high yield glycoprotein manufacturing.

An established fermentation process provides homogenous and stable glycosylation patterns as well as general consistant batch-to-batch product quality.

The GEX® technology is proven for:

  • Antibodies of different isotypes (e.g IgG1, IgG2, IgM, IgA)
  • Defucosylated antibodies
  • Bispecific antibodies
  • Complex glycosylated antibodies and proteins
  • Blood-factors
  • Protein hormones
  • Enzymes
  • Scaffolds   

Regulatory Approval/Endorsement

GEX® has regulatory approval by FDA, EMA and German regulatory authorities (PEI, BfArM) for manufacturing of biopharmaceuticals.