Our cell line development provides a safe and cost-efficient basis for your project. With our cell line platforms we offer solutions for all clients and products, be it extreme titers, extra fast development times, fully human and/or specific glycosylation patterns, or the efficient expression of very difficult to express proteins.
Have a look on our cell line technologies
Our USP development team is highly experienced and provides you with robust and cost-efficient processes. We have developed media and know how to adapt and to optimize them in order to increase expression titer, strengthen cell viability. On average, we double and sometimes more than triple the titer of a developed cell line during the USP development.
Efficiency is key for a good downstream process : to consistently obtain a pure and high quality product while recovering as much target protein as possible. Celonic has set-up a downstream platform process for antibodies recovering more than 75 % of the target protein. This saves you considerable development time and costs. In addition our experience in process development for non-antibody products enables us to maximize the recovery rate during platform adaptation.
Our GMP facilities at our two locations are top-of-the-line. Therefore, we can promise drug substance manufacturing under cGMP. Our multiple GMP suites are ready for fed-batch and perfusion production in single-use or stainless steel bioreactors. Celonic’s USP and DSP platform technologies together with an integrated quality control system and total quality management are adapted to deliver best-in-class material for your clinical trial or commercial product.
This is why, we consistently deliver high class biologics for our clients therapeutic areas. No molecule is too difficult for us. We have GMP processes ready for human and CHO cell lines.
To increase speed to clinic of your future medicine, we offer you our fill and finish services for liquid formulated drug products. The production of the clinical samples can be done in a highly flexible facility setup. We adapt the GMP-compliant process to the dosage, formulation and filling needs for your drug product.