fed-batch cell culture
We have developed many continuous and fed-batch bioprocesses to manufacture complex proteins.
Our manufacturing philosophy is based on single use technologies. For fed-batch and perfusion processes we have single use bioreactors of up to 1000 L in operation. Our Heidelberg facility routinely performs perfusion processes with up to 2000 L harvest volume per day over 30 days. For cell retention we are able to / can apply different systems like centrifugation and Alternating Tangential Flow.
We consistently deliver high-quality batches of:
- Monoclonal antibodies
- Complex biologics including:
- fusion proteins
- blood factors
- bispecific antibodies
- antibody fragments
- biologics with complex glycan profiles
- Human and rodent (CHO) cell lines.
20 years of optimizing perfusion technique
The promise of perfusion
As a key industry player, Celonic is spearheading the developing and refining of perfusion processes.
What are the advantages of perfusion?
- Cost Savings
- Product Quality