CHOvolution™: An extremely productive and stable CHO-based expression system for biopharmaceuticals
CHOvolution™ is a CHO-K1 based expression platform that can be used for a broad range of applications, ranging from non‑GMP R&D testing to GMP development and commercial market supply, with a support system to help throughout every step of development.
Besides offering cell line development services, Celonic is selling/outlicensing the system to other service provider or drug developers.
The CHOvolution™ technology is proven for:
- Antibodies of different isotypes (e.g. IgG1, IgG2, IgG4)
- Bispecific and single chain antibodies
- Enzymes, growth factors and hormones
Its key features are :
- Cell line adapted to serum-free EMA and FDA compliant media
- Simplified licensing model (e.g. no royalties from sales)
- High productivity (up to 7.6 g/l for mABs)
- High scale-up stability (over the 120 generation cycles and easily scalable from shake flask to >1000L)
- GMP compliant, from R&D to market manufacturing
- Tailored workshops and hands-on training to develop the product
- Technical and scientific support on the CHOvolution™ platform